Treatment Protocols

If you are a patient on GcMAF, please check back here regularly for new information.

Please note that we are scientists, not doctors. We do NOT suggest you abandon any life saving treatment. If you are on rigorous medications, always confer with your specialist and ask for progress reports before making any changes to your treatment regime.

Under the UK GMC Good Prescription Guidelines paragraph 68 a doctor may use the treatment of his choice. You have a legal right to choose your medication – Declaration of Helsinki (1975). If you have a cancer with tumours, for the Home Protocol the dosage is:
1. For stage one, a standard dose of 0.25ml GcMAF twice a week, for stage 2 three doses a week, stage 3 five doses a week, late stage 4 up to a full 1ml five times a week. You should expect no side effects with 1ml a day.
2. At least 10,000iu of vitamin D3 a day, 100mcg K2, 400mg of magnesium citrate.
3. No sugar or carbohydrates (so no cereals or bread etc) which feed cancer.
4. Eat vegetables, fish, and white meat.
5. If your weight drops below your perfect weight for your height, take Branch Chain Amino Acids (BCAA) from a vitamin shop, or better, Master Amino Acid Pattern.

If nebulising the dose is 0.5ml to 1.0 ml a day in 5ml of saline.

If you add drugs to this, the more you add the more you will reduce your chances of success. More is less.

Don’t stop the GcMAF until 8 weeks after you have scans proving you are cancer free, or 8 weeks after your nagalase drops below 0.65.

GcMAF is usually successful with terminal stage four pancreatic cancer, but it takes doses of one ml a day initially. Chemotherapy can make blood and immune system counts so low treatment fails.

Avoid the five main causes of cancer
1. Too much sugar
2. Lack of vitamin D3
2. Poor nutrition lacking in amino acids and trace metals,
4. Lack of oxygen and exercise,
5. Severe shock stress.

From GcMAF’s discovery in 1990 until 2013, 0.25ml of GcMAF a week was recommended, because it was thought GcMAF only rebuilt the immune system and activated macrophages, where it has a half life of 6 days. In 2013 we carried out laboratory research and published research papers (See “the Science” here) in which we discovered four more attacks GcMAF has on cancer, three excellent results on the brain, and two on cells. These have a half life of 3 days. Coupled with feedback over four years, we’ve now re-adjusted the dosing. So for cancer we now suggest at least two 0.25 doses a week, which is enough for good responders. In our Treatment Centres our doctors give a maximum of 2ml, one vial a day for 2 days only, because the body cannot transport cancer debris away at that level. The most we give continually is 1ml a day.

If you are treating an infection or a cold, give one 0.25-0.5 shot only. It may be gone in 36 hours. If you take shots every day, the immune system will be kept high, producing mucous and maintaining the symptoms long after the cold should have left.

Avoid sugars
Stay away from: sugar, which feeds cancer, carbohydrates which turn into sugar; and grains beans and potatoes, which also contain cancer inducing lectins and poisons – wheat is the worst. Avoid soya milk which blocks the absorbance of trace metals.
Some sweeteners are damaging in other ways – asparthame lowers your immune system; even Splenda is a chlorocarbon like DDT –    See
The best appears to be the natural plant sweetener Xylitol or Stevia, to which they add relatively harmless maltodextrin for supermarkets. Second best is saccharin.
Breast cancer
If you have a root canal, you are advised to have that tooth removed. (See article)
And ordinary milk contains estrogen, which is a growth factor for uterine cancer, and for breast cancer but less so.
Stage 4 cancer
GcMAF has six attacks on cancer; four direct, where its half life is three days. So most importantly increase the GcMAF dosage, and put into different parts of the body at least twice a week. As a macrophage activator its half life is 5 days (the half life of macrophages is 6 days). These 5 attacks start up in within minutes. You can see the increase in activity in the spleen on live scans. The sixth attack, the immune system, is fully rebuilt by GcMAF in 3 weeks. IV by a doctor is best.

There are out-patient Treatment Centres in Europe where doctors use ultrasonography to accurately measure your tumors, and to place the GcMAF in the right place every day for a week or more. Re-measure a week later and a 25% reduction in the first week is average.

If you can have surgery to reduce tumour mass, do so, but make sure you are on GcMAF for at least three weeks before the surgery and 8 weeks afterwards, so that your rebuilt immune system can prevent secondaries caused by cancer cells released by surgery settling elsewhere.

And then keep the GcMAF up for 8 weeks after scans show your tumours are gone, or nagalase first drops below 0.65.

Perhaps 10% of autistic children react badly to having their immune system rebuilt. For that reason a child starts at 0.03ml, with a second 0.03 dose in three days, to build up to a twice weekly 0.1ml dose as soon as possible. The final dose is dependent on body weight. The closer to adult size, the closer to the 0.25ml adult dose they should go.

Many autistic children have very high levels of vitamin D3, and low levels of vitamin D2. We do not recommend vitamin D3 in autism without a vitamin D blood test.

Please see this page for more info – Autism

In ME/CFS GcMAF will rebuild the immune system, which will challenge dormant viruses. They may fight back with a milder “Iris” type reaction. For that reason start on a 0.03ml dose, and every 4 days increase the dose by 0.01ml. When you reach a 0.1ml dose, you can go to a 0.25ml dose or more.

Myalgic Encephalomyelitis, ME, named Chronic Fatigue syndrome, CFS in the USA, is mainly a viral disease.

Some people with CFS have a reaction as their immune system is rebuilt. Participants are therefore advised to start on a low dose, 0.03ml, then 0.03ml on the fourth day, then 0.1ml after 7 more days. After that a normal shot of 0.25ml twice a week. If you have a reaction, stick to 0.3ml for four weeks, then try to increase again.

At the GcMAF Conference 2013 it has become clear that we are now eradicating ME/CFS in 50% of cases, a big improvement on the 30% full recoveries we were making last year. Subsequent data from our own CFS self help group shows another big increase to 70%, as people get further down the track. (June 2014: we now 85% cure 70% of participants)

ME/CFS is brought on by differing circumstances including a weakened immune system coupled with stress. The speed of recovery to normal health depends on the type of ME; variants include phosphate or pesticide poisoning, digestive, mitochondrial, liver or hormone imbalances.

People with ME/CFS have high nagalase and collapsed immune systems, because the viruses are preventing production of their own GcMAF.

We have about 120 ME participants on our GcMAF, many through the four of our 100 doctors who specialise in ME.

Although everyone promises on our website to give feedback, only about 15% do, so we have done some chasing up on ME and have just 35 replies. To be fair, we have no way of contacting those participants who went though doctors, and few doctors respond. (But this data below is now superceeded by the GcMAF conference results above.)

If you get worse temporarily that does not means the disease will not eventually be eradicated.

Unfortunately viruses are clever things. In the case of ME it seems they can block the VDR, conceal themselves with biofilms, and when their lives are threatened by an immune system rebuilt by GcMAF, they can arise from their dormant state and go on the attack, which can utterly exhaust you.  To avoid that you should start GcMAF with small, 0.05ml increasing doses,  and reduce the dose if your viruses wake up.

But some people simply improve.

Preliminary results from our trial show LDN blocks progress while on GcMAF.

With 8,000 people on it, we now know there are no side effects to our GcMAF itself. When there are side effects, it is the rebuilt immune system that causes them.

GcMAF / ME developments

We have no doubt that GcMAF and the immune system will prove to be the eventual cure for ME, and the GcMAF/ME research that we and other scientists have started will bring that about. 2014 – that has now happened with 70% being cured. In our clinics we are closer to 100%.

For the meantime, to improve on the above response rates, you need GcMAF, 10,000IU vitamin D a day, zinc, magnesium (Professor Stefania Pacini’s research) and probiotic yoghurt.

Cyder apple vinegar, grape seed extract, Bromelain and Papain may encourage enzymes to devour biofilms. And in ME, exercise sometimes does more damage than good.

If you wish to detox: Emulsified vitamin A, selenium and vitamin E (for the lymphatic system to carry away wastes). Non responders can respond if they take Chlorella with cod liver oil that has correct ratios of vit A to D. This binds to heavy metals and chelates them out and also offers absorption of missing minerals.

Don’t forget to eat plenty of lipids (meat and fish), the food of your immune system and neurological systems. Avoid vegetarian diets.

GcMAF, TNF-alpha and Alzheimers

Overproduction of TNF-alpha interrupts synaptic communications in the brain in Alzheimer’s and Parkinsons disease

GcMAF activated macrophages disable TNF-alpha by occupying its receptors

Alpha lipoic acid, coconut oil, magnesium, omega 3, vitamin D and E.  No sugar or carbs

We’ve now written four papers on these diseases:

American Journal of Immunology. Volume 9, Issue 3. Pages 78-84.
Therapeutic effects of highly purified de-glycosylated GcMAF in the immunotherapy of patients with chronic diseases.
It covers cancer, autism, chronic fatigue syndrome, Lyme disease, multiple sclerosis, amyotrophic lateral sclerosis.

Italian Journal of Anatomy and Embryology (2013) 118 (Suppl. 2): S143 (P28).
Vitamin D binding protein-derived macrophage activating factor stimulates proliferation and signalling in a human neuronal cell line.
Autism, chronic fatigue syndrome, multiple sclerosis and amyotrophic lateral sclerosis

Italian Journal of Anatomy and Embryology (2013) 118 (Suppl. 2): S144.
Treatment and Prevention of Cadmium-induced alterations on human neurons.

American Journal of Immunology. Published the 8th November 2013.
Effects of GcMAF on human neurons and ME/CFS treatment.

Neurodegenerative conditions

Multiple Sclerosis (MS), Acute brain traumas, Psychiatric disorders, Brain aging

Activation of macrophages appears to be essential in repairing central nervous system (CNS) lesions, such as those observed in MS.

In fact, monocyte-derived macrophages provide multi-functional contribution in various neurological conditions, ranging from acute traumas to neurodegenerative disorders.

The diverse functions of macrophages are manifested by induction and resolution of inflammation as well as their involvement in neural tissue regeneration and renewal, matrix remodeling and debris clearance (J Pathol. 2012 Sep 24. doi: 10.1002/path.4106)

These recent advances reveal a dramatic therapeutic opportunity for controlled harnessing of macrophages for repair of the damaged CNS following acute assaults, in neurodegenerative conditions, and in psychiatric disorders.
Therefore, activation of macrophages by GcMAF could prove useful in brain regeneration and repair

This leads to the hypothesis that GcMAF would slow the process of brain aging.
In fact, it has been recently proposed that monocyte-derived cells serving multiple roles within the brain have a long term impact on the functional vulnerability of the brain to environmental, physical, age-related, or disease-related assaults (Neurotoxicology. 2012 Mar;33(2):191-206)

We have just one man with Parkinsons whose symptoms dropped by 60% with GcMAF, insufficient data to draw conclusions yet. But it seems GcMAF needs to be taken continually to maintain the results.

This is very new science, and whereas GcMAF, as a part of all healthy people, won’t do any harm, we have as yet little proof this theoretical science works in practice. We understand drinking 4+ pints of water with silica (eg Volvic Spring water) a day to chelate aluminium, and taking himalayan Rock salt, high doses of the B vitamins, particularly B12, and high doses of vitamins C and E together should also help.

Kidney disease

There is one published paper:

The Vitamin D Axis in Chronic Kidney Disease – State of the Art and Future Perspectives

published in European Nephrology in 2011

Which states that “All the components of the vitamin D axis participate in the pathogenesis of chronic kidney disease (CKD). The vitamin D axis includes vitamin D, vitamin D receptor, vitamin D-binding protein (VDBP), and GcMAF.

In CKD proteins are lost, so less GcMAF is produced. And as a chronic disease elevated nagalase will be found. And if dialysis is used, inflammation will occurr.

in late stages cachexia (progressive weight loss, anorexia, erosion of body cell mass) occurs, and the immune system is collapsed.

We have just one person who took GcMAF with vitamin D and appears to have reversed chronic stage 3 kidney disease.


Liver disease including cirrhosis of the liver

GcProtein or VDBP is made in the liver. In advanced liver disease the production of GcProtein (and other proteins) is impaired, with the result GcMAF cannot be made in the blood. The immune system is therefore severely compromised.

Good nutrition is needed to make up for the lost proteins, and the pini score should be calculated. Branched amino acids like whey protein are needed to make up for some of those proteins, milk contains GcProtein, and external GcMAF is needed to rebuild the immune system. We have just one well documented case, which will shortly be formally published.

Liver cirrhosis due to Hepatitis B, one case fully recovered

Italy. Monitored by an Italian university research center (one of the best centers on hbv internationally) and a University professor who is also an MD. Started antivirals which made virus replication undetectable in the blood but did not clear hbv infection from the liver, no effect on immune status or general well being.

Before gcmaf: could not stand for long, could not walk for long, traveling taking airplane, trains, metro especially in big messy cities like Rome for my job used to kill me. Metro and city trains, both crowded or empty, made me feeling without any strength even just sitting. i could not breath like an asthma crisis probably due to chemicals and pollution and had to get off to breath some fresh air.

Sleep problems, i could sleep only after 1-2am by taking melatonin.  Used to get horrible infections like severe almost monthly flu with lungs bronchitis lasting a minimum of 5 weeks, never totally clearing candida infections in mouth, a simple cut in a leg lasting 2 months with antibiotics creams worsening the infection (could clear it only by pure honey, it took 2 months). After the GcMAF, all that’s gone now.

Nagalase. April 2011: 6.7.  Began GcMAF 15th May 2011.  Nagalase 1.5 on 10.1.12.

It took 1.6 years to fully recover from the liver cirrhosis, the researchers who saw such fast improvement were really surprised, and I am not aware of such fast improvement ever being reported before (about 50% can regress cirrhosis by 5-6 years of antiviral use but only partially, nodules don’t regress)

13/11/2009 Baseline Fibroscan was 15.9kpa, 1 started started antivirals on 17/11/2009, by 26/03/2010 it was 16,3kpa (worsened),
on the 01/05/2011 started gcmaf, 26/05/2011 6,3kpa (below 6 is normal), 07/02/2012 5,6kpa (fully normal), 16/10/2012 4,5kpa

Nodules on the cirrhotic liver are slowly regressing 2 years after the first GcMAF. Cirrhotic nodules are not report to regress on advanced

The GcMAF immune system rebuild has been completely successful. 10.1.12. Sure I am close to a complete cure. All diseases including HEP B, except HBV, gone, great immune system, none of the usual colds.  He also took the vitamin D and our relevant recommendations from “Treatment Strategies” on the left.

Sorry that is all we have until publication.

The bacteria is very good at hiding from the immune system using a process called biofilms. You need to break down these biofilms in order for Goleic or GcMAF to work.

Some people have used papaya, pineapple (the fibrous middle bit – bromelain) and serapeptase to try to flush them out of hiding and ideally the activated macrophages will recognise and deal with them.

They may fight back with a milder “Iris” type reaction. For that reason start on a 0.03ml dose, and every 4 days increase the dose by 0.01ml. When you reach a 0.1ml dose, you can go to a 0.25ml dose or more.

Please read the testimonial from one of our clients.

Below is feedback from one of our participants.

“A few more words about my experience with Lyme and GOleic.
I feel GOleic is absolutely an essential treatment in Lyme disease.
However, because Goleic helps the immune system to recover I think it makes the Lyme treatments much more effective.
To treat Lymes, I am currently just using herbs (primarily Andrographis and Cryptolepis for antimicrobials) and biofilm breaker Serrapeptase.
I am also using Colostrum to help my immune system and a host of other support nutrients (B-vitamins, Vitamin C, etc.).
I wasn’t having a lot of success until I added the GOleic to my protocol.
Since adding GOleic I am having a steady increase in my health. I did start with a high Nasalise level of 3.7, and some Lyme people may not have the significant viral co-infection that I have had, but I still feel most Lyme people will benefit greatly from the treatment.”

Another client who had Lyme’s for 9 years and was bedridden for the last 2 years, has now made a full recovery –

GcMAF is effective at restoring the immune system, and therefore against viral diseases. Most people are surprised that nebulisation of GcMAF is a non event. It can be stored frozen in a freezer at about -20 when it will last nearly 10 years. Don’t refreeze. Then after first used, store at + 4 degrees C, the temperature of a kitchen fridge, for 8 weeks.

Each vial of GcMAF contains 2.2 ml, enough for 8 doses of 0.25ml each. A course for stage one/two cancer is typically 24 weeks, stage four 52 weeks. Autistic children should start on 0.03ml.

Buy a nebuliser (a PariBoy is about €100) and follow the instructions.

You may become tired within 2-4 hours of the nebulisation as though you are fighting off flu; this is your immune system springing in to life.  If your immune system is low, it may take some weeks to get to this stage. Some never experience the tiredness.

In 0.3 percent of cases GcMAF causes your immune system to overproduce histamine; if you get symptoms buy some anti-histamine from any chemist (it’s a hay fever remedy).

GcMAF needs normal levels of vitamin D3 to function fully; we recommend 10,000 IU daily. Vitamin C in large quantities helps. Eat the ‘Caveman Diet’: meat, fish, vegetables and fruit. No sugar, grains beans or potatoes.

If you can, avoid medications that block or destroy the immune system (eg chemotherapy, steroids). Check for a full list.

Remember, don’t freeze GcMAF unless you are not going to use it for at least some weeks.

There is nothing you need to avoid while on GcMAF.

Worldwide there are six billion healthy people with GcMAF inside them, and you can take anything with our GcMAF that they can. So we are not aware of any contra indications for GcMAF itself.

But there are contra indications for your immune system, which you are trying to rebuild. Generally, do not take medications unless you have to.

So, for the sake of your immune system

You should continue with any supplements that help the immune system. Anti-histamine is fine.

However, try to avoid anything that suppresses your immune system (or you may nullify the good effects of GcMAF:)

LDN appears to stop the action of GcMAF, as do Tamoxifen and Letrozole.

Externally administered heparin (used to stop blood clots) can completely block GcMAF.

Aspartame -the well known sweetener – can negatively interact with your intestinal microflora and reduce your immune defences

All kinds of Corticosteroids (Prednisolon, Prednisone, Betapred, Solu-Cortef, Solu-Medrol etc). So avoid Cortisone and steroids if possible.

Anti- inflammatory drugs should be avoided. (NSAIDs like Ibuprofen, Diklofenalk. Celebrex Aspirin etc should be taken in moderation.)

Cytotoxic medications or chemotherapy (Cyclophosphamide (Sendoxan) Etoposide (Vepesid) Metotrexat, Taxotere, Taxol, Navelbine etc etc) although there is some evidence GcMAF may reduce the side effects and the damage these poisons do.

Radiation Therapy.

Morphine (Morfine) analogs, (Morfin, Tramadole, kodeine, Fentanylplasters, Oxynorm, Oxycodon etc). Take buprenorphine instead.

Dr Yamamoto also warns against beta blockers (seloken, Selo-Zok etc)

Carrageenan (Chocomel) can block macrophage (gcMAF) activity. Also known as E407 or E407a.

Remember, in men, high cortisol will cause a man to lose his testosterone down the road because cortisol will block testosterone from working at the cell receptor sites. A man will lose his sex drive and be 15 kgs overweight. He will frequently have high cholesterol and high triglycerides. It’s a perfect setup for a heart attack.

If you wish to speed your recovery you can:
1. Sunbathe whenever you can. We recommend 10,000 IU (225 micrograms) of vitamin D3 a day. On a blood test, you want to aim for a vitamin D level of 60-80 ng/ml,which is about 150 nmol/l  (multiply by 2.496).  Our participants who do well all have high vitamin D levels (and the rate of tumour mass reduction drops as winter approaches)
80 percent of cancer, CFS and HIV patients have low levels of vitamin D (under 30ng/ml). One day of sunbathing gives you 20,000 IU of Vitamin D. But GcMAF needs normal levels of vitamin D (40ng/ml+) to fully function.
Laboratory tests have shown GcMAF is 2.5 times more effective with normal levels of vitamin D.
Do not stop GcMAF until after your nagalase gets below 0.65, when your own GcMAF will take over again.
2. Take plenty of exercise, preferably in the sunshine, and breathe deeply. This gets oxygen around, and disease cannot stand it.
3. Drink at least 4 pints or 2.5 litres of water during a day.
4. Proper nutrition is essential. Get your PINI score checked. Its a blood test, and its: Alpha 1 acid glycoprotein x C-reactive protein / albumin x prealbumin. It should be below one. Eat plenty of lipids, the food of your immune system (see below)

5. High dose vitamin C – 25,000 IU during a day. Better still, get your doctor to give it IV. There are synergistic effects with GcMAF Or up to 10 grams (10,000mg) ascorbic acid. (Side effects appear at 50 grams a day.)
6. Detoxing: Emulsified vitamin A, selenium and vitamin E. This is for the lymphatic system to carry away wastes, and is important. Non responders can respond if they take Chlorella with cod liver oil that has correct ratios of vitamins A to D. This binds to heavy metals and chelates them out and also offers absorption of missing minerals.

7. Maintain an alkaline PH in your body. A teaspoon of bicarbonate of soda in water once a day or vegetables like pureed asparagus and broccoli. Broccoli sprouts are particularly good
8. DCA and Tallberg powders (which we supply) Vitamin B 17 (Apricot kernels), zinc, B17′s transport mechanism.
9. GcMAF performs better in the presence of oleic acid. Its an Omega 9 oil, the best source is olive oil.
10. Drink green tea. There are a couple of research papers on this.
11. Curcumin, specifically turmeric, is helpful with melanoma and breast cancer. Its difficult to get into the body. Try it liposomal.

The highest dose know is 16 shots or 4ml a day, but only for 2 days as the body cannot remove the cancer debris fast enough. The maximum continuous dose is 2ml a day. But in ME/CFS, autism and Lyme, we recommend you start with a very low dose of 0.03ml.

Food for your immune system (and neurological system)

Dr Tomas Tallberg MD, head of the Helsinki Institute for Bioimmunotherapy, has published numerous research papers over the last 40 years which state that lipids are needed to rebuild your immune and central nervous system where the patient has cancer or autism.

He states you are unlikely to recover if you are on a fast food diet, vegan or vegetarian diets, or processed foods.

Your immune and neurological systems need to be fed with the right amino acids, trace metals and lipids if GcMAF is to rebuild them:

You need the original human caveman diet without red meat or fruits, ie white meat, fish vegetables, and the lipids provided by butter, cream, chicken liver, salmon, nuts coconut milk, offal. (Unfortunately the fastest place to get lipids from is canned (prion free) pigs brain !